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KMID : 0903519950380020100
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
1995 Volume.38 No. 2 p.100 ~ p.105
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Media Optimization for the Production of Aminopeptidase M Inhibitors MR - 387A and B by Streptomyces sp . SL - 387
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이호재/Lee, Ho Jae
김수일/고영희/전효곤/정명철/이충환/Kim, Su Il/Kho, Yung Hee/Chun, Hyo Kon/Chung, Myung Chul/Lee, Choong Hwan
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Abstract
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Media optimization for the production of MR-387A and B, novel aminopeptidase M inhibitors by Streptomyces sp. SL-387 isolated from a soil was studied. Optimized medium was consisted of 1% glucose, 3% soybean meal, 0.2% yeast extract, 0.1% beef extract, 0.3% NaCl, 0.01% K₂HPO₄, 0.3% CaCO₃. 0.001% MnCl₂·4H₂O, 0.001% ZnCl₂·7H₂O, and 0.0005% MgSO₄·7H₂O, and adjusted to pH 7.0 before autoclaving. When the optimized medium was used as a fermentation medium, maximum productivity of MR-387 was reached at 120 hours of fermentation, and total productivity was 909.1 U/㎖.
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